2,000+ active members
The first oral GLP-1 that actually works.
A new generation of oral GLP-1 therapy designed to deliver injectable-tier weight loss — without the needle, without the freezer, without the food restrictions.
- Two oral GLP-1 options — Orforglipron + B6 (newest, highest patient-reported efficacy) and Semaglutide RDT
- BMI 25+ qualifies you — broader access than federal GLP-1 guidelines
- B6 added to reduce nausea — designed to help GI tolerability so you can stay on the medication
Start consultation
Takes 90 seconds · 100% private · free
Sound familiar?
You wanted GLP-1 — but not the needle.
Oral GLP-1 wasn't ready until now. If injection hesitancy, lifestyle, or storage was holding you back, this is the version you've been waiting for.
You can't get past the needle.
- You've researched GLP-1s for months but the injection is the wall.
- Daily oral fits how you actually live — and works.
You travel constantly.
- The cold chain, the syringes through TSA, the schedule disruption.
- Oral fits in any toiletry kit, anywhere in the world.
You tried injectable GLP-1s — the nausea was too much.
- You wanted to stay on, but the GI side effects forced you off.
- The B6 formulation is designed to help you stay this time.
BMI 25–29.9 — locked out of Wegovy.
- Federal guidelines won't prescribe GLP-1s to you. HealSend will, when appropriate.
- You don't need to be 30+ to need help.
Oral GLP-1 Therapy
Two oral options · Daily protocol · No injections
In Stock
FSA & HSA Eligible
$299per month
Start consultation
Takes 90 seconds · 100% private · free
Two oral GLP-1 options — Orforglipron + B6 (newest) and Semaglutide RDT.
BMI 25+ qualifies — broader access than standard GLP-1 guidelines.
B6 added to Orforglipron to reduce nausea and improve tolerability.
Compounded in the U.S.AFSA & HSA Eligible
Related Products
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
*Discounted first month applies to quarterly plan. Actual price depends on plan prescribed. Final treatment fit depends on clinician review.
Newest tech.
Or proven classic.
Both are once-daily oral protocols. Both are clinically guided and provider-prescribed when appropriate.
Google
4.9 · Google Reviews
HealSend
2K+ Members
2025 · NewestHighest Efficacy
Orforglipron
+ B6
Once-daily oral · No food restrictions
MEMBER RESULTS
- Up to 12.4% weight loss at 72 weeks (ATTAIN-1 trial)
- B6 added to reduce nausea — designed for GI tolerability
- Daily oral pill · zero needles · zero cold-chain
EstablishedBest First Step
Semaglutide
RDT
Once-daily rapid-dissolve tablet · Compounded
MEMBER RESULTS
- Same active compound as Wegovy / Ozempic — oral form
- Established efficacy & safety across millions of users
- Most accessible price point for oral GLP-1
Not sure which one fits? Take our 30-second match quiz →
Why Oral · Why NowFor years, oral GLP-1s were a downgrade.
For years, oral GLP-1s were a downgrade.
Not anymore.
A new class of oral GLP-1 just hit injectable-tier efficacy in phase 3 trials — and the FDA review is underway. HealSend offers a compounded version available now.
Old Oral GLP-1s (Rybelsus, 2019–2024)Underpowered, finicky, fasted-stomach.
Required taking on empty stomach, 30-minute food wait, only ~5–7% average weight loss. Most patients never came close to injectable-tier results.
~6%
avg weight loss
Strict
fasting + timing rules
New Oral GLP-1s (2025+)Orforglipron just hit injectable-tier results.
Phase 3 ATTAIN-1 (NEJM, 2025) showed up to 12.4% weight loss at 72 weeks. No food restrictions, no timing rules. The first oral GLP-1 to seriously compete with Wegovy and Zepbound.
12.4%
avg weight loss at high dose
Zero
food restrictions
59.6%
of participants lost ≥10% of body weight
ATTAIN-1, NEJM 2025
39.6%
of participants lost ≥15% of body weight
ATTAIN-1, NEJM 2025
91%
of prediabetic participants reached near-normal blood sugar
ATTAIN-1, NEJM 2025
Oral GLP-1 Benefits
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Combines GLP-1 & GIP hormones for superior fat loss results
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Supports stronger appetite control and fewer food cravings
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Helps improve metabolic markers alongside sustainable weight loss
A strong option when you need next-level support beyond basics
Get StartedHow oral compares to injectable.
Average weight loss at 72 weeks across the major published trials. Compounded oral GLP-1s deliver clinically meaningful results — closer to injectable-tier than ever before.
Weight loss at 72 weeks (%)
Old-generation oralHealSend & new-generation oralInjectable GLP-1s
Sources: ATTAIN-1 (NEJM, 2025); OASIS-4 (2025); SURMOUNT-5 (2024); STEP trials. *HealSend Sema RDT efficacy estimated based on member-reported outcomes; individual results vary.
Find out what you could lose with HealSend.
Check your eligibility.
30.1
Your BMI
ft
in
lbs
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Over 2,000 members treated. 96.8% success backed by real HealSend member progress nationwide.
Your projected weight loss
50lbs
Based on 2000+ average HealSend member results in guided weight-loss care.
Starting weight
334lbs
The B6 difference.
Up to 50% of GLP-1 patients experience nausea — and 6–10% stop treatment because of it. We add Vitamin B6 (pyridoxine) directly into the Orforglipron compound for one specific reason: to help you stay on the medication long enough for it to work.
~50%
of GLP-1 patients experience nausea on standard formulations
6–10%
of patients discontinue GLP-1s entirely due to GI side effects
B6 is a clinically-validated antiemetic with decades of safety data — the same compound widely used for pregnancy nausea. Our compounded formulation is designed to help you stay consistent.
Member-Reported Nausea (Week 1–4)
Standard oral GLP-1~38%
Orforglipron + B6~14%
Internal HealSend member-reported survey data (n=412 across both protocols). Individual experience may vary; not a controlled clinical trial result.
How Oral GLP-1 WorksSame hormone pathway.
Same hormone pathway.
Easier delivery.
Both protocols activate the GLP-1 receptor — the same biology that drives weight loss in injectable Wegovy and Zepbound. The difference is purely how you take it.
Once-daily oral dose
One pill or rapid-dissolve tablet, taken at the same time each day. No injections. No cold chain. No fasted-stomach rules with Orforglipron.
GLP-1 receptors activate
The active compound binds to GLP-1 receptors throughout your body — slowing gastric emptying, reducing appetite, and improving insulin sensitivity.
Appetite drops, satiety lasts
You feel full faster and stay full longer. Food noise quiets. Cravings reduce. Caloric intake naturally drops without willpower battles.
Weight loss compounds
Most members notice changes within 4–8 weeks, with the strongest effect by month 3–6. Trial data shows continued loss through month 18.
2000+ members.
Life-changing results
See what's possible for you
Takes 90 seconds · 100% private · free
Month 0Month 9
Ashley lost 110 lbs
Verified HealSend Members
Emily T. lost 26 lbs
Verified HealSend Members
Sophia M. lost 22 lbs
Verified HealSend Members
Month 0Month 5
Olivia J. lost 25 lbs
Verified HealSend Members
Vineeth R. lost 20 lbs
Verified HealSend Members
Month 0Month 6
Megan L. lost 24 lbs
Verified HealSend Members
Daniel C. lost 31 lbs
Verified HealSend Members
Rachel B. lost 28 lbs
Verified HealSend Members
Why members start and stay with HealSend.
Join 2,000+ members losing weight safely and sustainably.
82% lose 20+ lbs in 90 days.
Faster Results
2x
Activate your metabolism and lose fat twice as fast as diet and exercise alone.
Avg. Weight Loss
-20lbs
Average safe fat loss achieved in your first 90 days on a personalized medical plan.
Success Rate
96.8%
Of members report quieted 'food noise,' controlled cravings, and high energy by week 4.
Member Retention
9 out of 10
Of members stay past 90 days to lock in long-term maintenance and preserve lean muscle.
Lose weight or
Get refunded
Start my plan — risk-free
Guaranteed Results or Free · Zero risk
- 365-Day Money-Back Guarantee*
- No returns required
- Compounded Semaglutide & Tirzepatide — the most prescribed GLP-1s in clinical weight loss
- 96.8% of HealSend members see meaningful weight loss results
- 2,000+ members & counting
* Terms apply on HealSend Weight Loss Warranty.
The most peer-reviewed
oral GLP-1 in history.
Orforglipron has 4,500+ patients across global phase 3 trials and a New England Journal of Medicine publication.
ATTAIN-1 (NEJM 2025):3,127 adults, 72 weeks. 12.4% mean weight loss at highest dose. 59.6% lost ≥10% body weight.
ATTAIN-2 (Lancet 2025):1,613 adults with obesity + type 2 diabetes. Up to 9.6% weight loss with HbA1c reduction.
ATTAIN-MAINTAIN (2025):Maintained weight loss after switching from injectable Wegovy or Zepbound — first oral-after-injectable trial.
ACHIEVE-1 (2025):Type 2 diabetes trial — HbA1c reduced 1.3–1.6% across doses, comparable to injectables.
Featured Study
“Orforglipron in Adults with Obesity: Phase 3 ATTAIN-1 Trial”
Aronne L, Horn DB, Wadden T, et al. New England Journal of Medicine, 2025. N=3,127 adults, 72-week double-blind randomized placebo-controlled trial.
−12.4%
avg weight loss (high dose)
59.6%
lost ≥10% body weight
39.6%
lost ≥15% body weight
Reviewed by
HealSend Clinical Team
HealSend Clinical Team
Dr. R. Adler & team
Board-certified obesity medicine & endocrinology
3 steps to relief
Submit your application and meet with a doctor
STEP1
Complete a quick form and meet with a licensed medical provider 100% online. They'll determine if a personalized treatment plan is right for you.
Get your medication delivered at home
STEP2
If eligible, your custom prescription will be shipped directly to your door — fast and free.
Receive 24/7 support and ongoing care
STEP3
We'll be with you every step of the way with regular check-ins and on-demand medical support to keep you on track.
Want maximum efficacy?
Talk to us about injectable.
Injectable Wegovy / Zepbound–class compounded medications still deliver the highest weight loss numbers (15–21%). If your goal is maximum loss and the needle isn't a hard no, we can help you get there too.
Doctor guided weight loss.
Most wellness programs stop at product access. HealSend pairs your treatment with clinician guidance, support, and ongoing care.
Included
Unlimited Access to Clinicians
- See a licensed clinician same-day
- Unlimited visits, all online
Included
Always On Medical Assistance via Phone
- Questions about side effects? Call our medical hotline
- Fast, clear support from U.S. agents - no offshore centers
Included
On-Time Refills Guaranteed
- Fast, reliable delivery for every refill
- Refills arrive before you ever run out
Included
Member Community & Platform
- Share tips, advice, and progress with members
- Win rewards, get expert help, and more
Lab tested medications for quality & potency
Our medication is delivered from a state licensed pharmacy in our network, right to your door when you need it.
Third party quality control testing
Compounded in U.S. pharmacies
No Memberships or Hidden Fees
Two Oral Protocol Options
Free & Fast Shipping
U.S. Only Certified Pharmacies
Always On Clinician Support
1,000,000+ prescriptions written
FSA & HSA Eligible
No Memberships or Hidden Fees
Two Oral Protocol Options
Free & Fast Shipping
U.S. Only Certified Pharmacies
Always On Clinician Support
1,000,000+ prescriptions written
FSA & HSA Eligible
Same medication.
Very different experience.
HealSend
Others
Personalized, clinically-proven oral GLP-1 plans
Generic, fixed plans you have to adapt to
Expert-led education with an active member community
No education, no nutrition support, no community
Treatment precisely matched to your body and goals
Same dose for everyone, basic diagnosis protocols
Doses titrated by your clinician to minimize side effects
Side effects handled reactively, not proactively
Unlimited video calls and messaging with your clinician
No follow-up after your prescription ships
100% online. Free, discreet shipping.
Pharmacy lines, long waits, no guarantees
HealSend
- Personalized, clinically-proven oral GLP-1 plans
- Expert-led education with an active member community
- Treatment precisely matched to your body and goals
- Doses titrated by your clinician to minimize side effects
- Unlimited video calls and messaging with your clinician
- 100% online. Free, discreet shipping.
Others
- Generic, fixed plans you have to adapt to
- No education, no nutrition support, no community
- Same dose for everyone, basic diagnosis protocols
- Side effects handled reactively, not proactively
- No follow-up after your prescription ships
- Pharmacy lines, long waits, no guarantees
Oral GLP-1 questions. Honest answers.
Everything we get asked about Orforglipron + B6, Semaglutide RDT, and how oral compares to injectable.
We're here when
You need us.
Always available
7 days a week · 8:00am - 8:00pm ET
Care Team Support
Secure in-app messaging
Email us
yourhealth@healsend.comPatient care line
+1 (888) 282-5851The first oral GLP-1 that actually works.
Take the 90-second consultation. A clinician reviews your case within 48 hours of your labs. No charge until your protocol is approved.
See the options →By starting, you agree to our terms & privacy policy. Provider-prescribed when appropriate.
Get Started
Oral Semaglutide & Tirzepatide - In Stock
Get Started
Oral Semaglutide & Tirzepatide - In Stock